Anti-Cox-1; clone 5C5.1

Code: MABN628 D2-231

Application

Research CategoryNeuroscience

Research Sub CategoryDevelopmental Signaling

Immunohistochemistry Analysis: A 1:500-2,000 dilution from a representative...


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€457.00 EACH
€562.11 inc. VAT

Application

Research CategoryNeuroscience

Research Sub CategoryDevelopmental Signaling

Immunohistochemistry Analysis: A 1:500-2,000 dilution from a representative lot detected Cox-1 in human thalamus, human kidney and human cerebellum tissue.

Detect Cox-1 using this Anti-Cox-1 antibody, clone 5C5.1 validated for use in western blotting & IHC.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Cox-1, also known as Cytochrome C oxidase subunit 1, Cytochrome C oxidase polypeptide I, and encoded by the gene MT-CO1, CO1, COX1, MTCO1, is the catalytic subunit of Cytochrome C oxidase that forms the final reduction of oxygen to water in the respiratory chain. Subunits 1-3 form the functional core. Electrons originating in Cytochrome C are transferred via the copper A center of subunit 2 and the heme A of subunit 1 to the bimetallic center formed by the heme A3 and Copper B. The Cox-1 gene is encoded in the mitochondrion and the protein localizes to the inner mitochondrion membrane. It is expressed in all cells that contain functional mitochondria and mutations in Cox-1 are associated with various mitochondrial dysfunctional diseases that manifest themselves in defective vision, anemia, cardiomyopathy, muscle weakness and even some forms of cancer.

Immunogen

KLH-conjugated linear peptide corresponding to human Cox-1.

Physical form

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Protein G Purified

Format: Purified

Quality

Evaluated by Western Blotting in HeLa cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected Cox-1 in 10 µg of HeLa cell lysate.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Target description

~65 kDa observed. Uncharacterized band(s) may appear in some lysates.

antibody formpurified antibody
antibody product typeprimary antibodies
biological sourcemouse
clone5C5.1, monoclonal
concentration1 mg/mL
Gene Informationhuman ... MT-CO1(4512)
isotypeIgG1κ
NCBI accession no.YP_003024028
Quality Level100
shipped inwet ice
species reactivityhuman
technique(s)western blot: suitable, immunohistochemistry: suitable
UniProt accession no.P00395
This product has met the following criteria to qualify for the following awards:



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